A RING to rule them all: RING1 as silencer and activator

Dev Cell. 2014 Jan 13;28(1):1-2. doi: 10.1016/j.devcel.2013.12.015.

Abstract

Polycomb proteins are known for silencing their target genes during development and cell differentiation. Reporting in Developmental Cell, Kondo et al. (2014) now show that Polycomb factors can also participate in gene activation by orchestrating the 3D chromatin structure changes involved in transcriptional activation of their target genes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Enhancer Elements, Genetic*
  • Homeodomain Proteins / metabolism*
  • Mesencephalon / metabolism*
  • Polycomb Repressive Complex 1 / metabolism*
  • Prosencephalon / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Homeodomain Proteins
  • Mrg1 protein, mouse
  • Polycomb Repressive Complex 1
  • Rnf2 protein, mouse
  • Ubiquitin-Protein Ligases