Contrasting the glial response to axon injury in the central and peripheral nervous systems

Dev Cell. 2014 Jan 13;28(1):7-17. doi: 10.1016/j.devcel.2013.12.002.


Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and CNS is the pro- and antiregenerative responses of their glial cell populations. In addition to intrinsic qualities of the neurons themselves, glial-driven changes to the neural environment have a significant impact on regenerative outcome. This Review presents a comparison of the glial response to injury between the CNS and PNS and highlights features of the PNS glial response that, with continued study, might reveal long-sought-after keys to achieving CNS repair.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / physiology*
  • Central Nervous System / injuries
  • Central Nervous System / physiology*
  • Extracellular Matrix / metabolism
  • Humans
  • Myelin Sheath / metabolism
  • Nerve Regeneration*
  • Neuroglia / metabolism
  • Neuroglia / physiology*
  • Peripheral Nervous System / injuries
  • Peripheral Nervous System / physiology*