Neutrophil survival in the death zone

Blood. 2014 Jan 16;123(3):307-8. doi: 10.1182/blood-2013-11-538298.


In this issue of Blood, Thompson et al reveal a key role for hypoxia-inducible factor (HIF)-2a in the adaptation of neutrophils to hypoxia. Tissue hypoxia is a common feature of trauma and inflammation. Infiltrating neutrophils must adapt to this low-oxygen environment to satisfy the metabolic and functional demands of an immune response.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Inflammation*
  • Neutrophils / metabolism*


  • Basic Helix-Loop-Helix Transcription Factors
  • endothelial PAS domain-containing protein 1