Acute exposure to a 2 mT static magnetic field affects ionic homeostasis of in vitro grown porcine granulosa cells

Bioelectromagnetics. 2014 Apr;35(3):231-4. doi: 10.1002/bem.21838. Epub 2014 Jan 16.

Abstract

In this work, we provided direct evidence for the first time that exposure to a static magnetic field (SMF) of low intensity (2 mT) is immediately followed by a reversible cell membrane depolarization wave (of about 1 min) that causes the rise of intracellular calcium and the decrease of mitochondrial activity of vital granulosa cells. These effects are likely due to the increase in Na(+) and Ca(2+) cell membrane permeability.

Keywords: confocal microscopy; granulosa cells; ionic homeostasis; static magnetic field; swine.

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Cell Membrane / physiology
  • Cell Membrane Permeability
  • Cells, Cultured
  • Extracellular Space / metabolism
  • Female
  • Granulosa Cells / physiology*
  • Homeostasis*
  • Intracellular Space / metabolism
  • Magnetic Fields*
  • Membrane Potentials
  • Mitochondria / physiology
  • Sodium / metabolism*
  • Swine
  • Voltage-Gated Sodium Channels / metabolism

Substances

  • Calcium Channels
  • Voltage-Gated Sodium Channels
  • Sodium
  • Calcium