Medicine. How thalidomide works against cancer

Science. 2014 Jan 17;343(6168):256-7. doi: 10.1126/science.1249543.

Abstract

The surprising ability of thalidomude and its analogs to treat various hematologic malignancies is through the loss of two transcription factors.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents / pharmacology*
  • Humans
  • Ikaros Transcription Factor / metabolism*
  • Lenalidomide
  • Multiple Myeloma / metabolism*
  • Peptide Hydrolases / metabolism*
  • Teratogens / pharmacology*
  • Thalidomide / analogs & derivatives*
  • Thalidomide / pharmacology
  • Ubiquitin-Protein Ligases

Substances

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents
  • CRBN protein, human
  • IKZF1 protein, human
  • IKZF3 protein, human
  • Teratogens
  • Ikaros Transcription Factor
  • Thalidomide
  • Ubiquitin-Protein Ligases
  • Peptide Hydrolases
  • Lenalidomide