Abstract
A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2–21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.
MeSH terms
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Alkaloids / analysis*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Anti-Inflammatory Agents / analysis*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Cell Line
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Dipsacaceae / chemistry*
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Glucosides / analysis*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Iridoids / analysis*
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Lipopolysaccharides / immunology
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Macrophages / drug effects
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Macrophages / immunology
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Mice
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Nitric Oxide / immunology
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Plant Roots / chemistry
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Pyridines / analysis*
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Pyridines / isolation & purification
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Pyridines / pharmacology
Substances
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Alkaloids
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Anti-Inflammatory Agents
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Glucosides
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Iridoids
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Lipopolysaccharides
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Pyridines
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Nitric Oxide
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pyridine