Differences between transfer RNA molecules

J Mol Biol. 1987 Apr 20;194(4):635-42. doi: 10.1016/0022-2836(87)90240-3.


Computer-assisted comparisons of 67 tRNA sequences that function in Escherichia coli or Salmonella typhimurium were used to identify single and multiple nucleotide positions that maximally distinguish the 20 amino acid acceptor groups. Positions in the anticodon were identified most frequently, as expected from the decoding function of this region of the tRNA. The biological function, if any, of positions outside the anticodon may include specificity for aminoacyl-tRNA synthetase enzymes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids
  • Base Sequence
  • Computers
  • Escherichia coli / genetics
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • RNA, Bacterial / classification*
  • RNA, Transfer / classification*
  • Salmonella typhimurium / genetics
  • Software


  • Amino Acids
  • RNA, Bacterial
  • RNA, Transfer