The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

Nature. 1987 Oct 8-14;329(6139):512-8. doi: 10.1038/329512a0.


Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens / metabolism*
  • Binding Sites
  • Computer Graphics
  • Cytotoxicity, Immunologic
  • Epitopes
  • HLA Antigens / metabolism*
  • HLA-A2 Antigen
  • Humans
  • Models, Molecular
  • Polymorphism, Genetic
  • Protein Conformation
  • Receptors, Immunologic / metabolism
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / immunology


  • Antigens
  • Epitopes
  • HLA Antigens
  • HLA-A2 Antigen
  • Receptors, Immunologic