Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine

PM R. 2014 Jan;6(1):70-7. doi: 10.1016/j.pmrj.2013.08.612.


The use of stem cells in orthopedics has been researched for many years, with robust animal data that show efficacy in cartilage healing, tendon repair, and intervertebral disk treatment. Early clinical data are also just starting to be published, and these results are encouraging. Safety data in large case series, some that lasted for many years, have also been published. The field of tissue engineering with stem cells in musculoskeletal impairments has the potential to reduce morbidity and improve clinical outcomes. The regulatory environment for this area of medicine is still developing.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / cytology
  • Animals
  • Biological Therapy / trends
  • Bone Marrow Cells
  • Cell Differentiation
  • Cells, Cultured
  • Government Regulation
  • Humans
  • Intervertebral Disc Degeneration / therapy
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / physiology*
  • Osteoarthritis / therapy*
  • Tissue and Organ Harvesting
  • Translational Research, Biomedical
  • Transplantation, Autologous
  • Transplantation, Homologous
  • United States
  • United States Food and Drug Administration