Acute caloric restriction improves glomerular filtration rate in patients with morbid obesity and type 2 diabetes

Diabetes Metab. 2014 Apr;40(2):158-60. doi: 10.1016/j.diabet.2013.12.006. Epub 2014 Jan 14.


Aim: The role of caloric restriction in the improvement of renal function following bariatric surgery is still unclear; with some evidence showing that calorie restriction can reduce proteinuria. However, data on the impact of caloric restriction on renal function are still lacking.

Methods: Renal function, as measured by glomerular filtration rate (GFR), was evaluated in 14 patients with type 2 diabetes mellitus, morbid obesity and stage 2 chronic kidney disease before and after a 7-day very low-calory diet (VLCD).

Results: After the VLCD, both GFR and overall glucose disposal (M value) significantly increased from 72.6 ± 3.8 mL/min/1.73 m(-2) BSA to 86.9 ± 6.1 mL/min/1.73 m(-2) BSA (P=0.026) and from 979 ± 107 μmol/min(1)/m(2) BSA to 1205 ± 94 μmol/min(1)/m(2) BSA (P=0.008), respectively. A significant correlation was observed between the increase in GFR and the rise in M value (r=0.625, P=0.017).

Conclusion: Our observation of improved renal function following acute caloric restriction before weight loss became relevant suggesting that calory restriction per se is able to affect renal function.

Keywords: Caloric restriction; Diabetes mellitus; Glomerular filtration rate; Morbid obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism*
  • Caloric Restriction* / methods
  • Creatinine
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Male
  • Middle Aged
  • Obesity, Morbid / complications
  • Obesity, Morbid / diet therapy*
  • Obesity, Morbid / metabolism
  • Proteinuria
  • Treatment Outcome
  • Weight Loss*


  • Blood Glucose
  • Insulin
  • Creatinine