Missense variant in TREML2 protects against Alzheimer's disease

Neurobiol Aging. 2014 Jun;35(6):1510.e19-26. doi: 10.1016/j.neurobiolaging.2013.12.010. Epub 2013 Dec 21.

Abstract

TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11. Recent studies have identified a rare coding variant (p.R47H) in TREM2 that confers a high risk for Alzheimer's disease (AD). In addition, common single nucleotide polymorphisms in this genomic region are associated with cerebrospinal fluid biomarkers for AD and a common intergenic variant found near the TREML2 gene has been identified to be protective for AD. However, little is known about the functional variant underlying the latter association or its relationship with the p.R47H. Here, we report comprehensive analyses using whole-exome sequencing data, cerebrospinal fluid biomarker analyses, meta-analyses (16,254 cases and 20,052 controls) and cell-based functional studies to support the role of the TREML2 coding missense variant p.S144G (rs3747742) as a potential driver of the meta-analysis AD-associated genome-wide association studies signal. Additionally, we demonstrate that the protective role of TREML2 in AD is independent of the role of TREM2 gene as a risk factor for AD.

Keywords: Alzheimer's disease; Association; Conditional analysis; Endophenotype; Gene; Genome-wide association studies; TREM2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / prevention & control
  • Biomarkers / cerebrospinal fluid
  • Chromosomes, Human, Pair 6
  • Genetic Variation / genetics*
  • Genome-Wide Association Study*
  • Humans
  • Meta-Analysis as Topic
  • Mutation, Missense / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / physiology
  • Risk

Substances

  • Biomarkers
  • Receptors, Immunologic
  • TREML2 protein, human

Grant support