Mycobacterial lipid logic

M Sloan Siegrist; Carolyn R Bertozzi

doi:10.1016/j.chom.2013.12.005

Mycobacterial lipid logic

Cell Host Microbe. 2014 Jan 15;15(1):1-2. doi: 10.1016/j.chom.2013.12.005.

Authors

M Sloan Siegrist¹, Carolyn R Bertozzi²

Affiliations

¹ Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: crb@berkeley.edu.

Abstract

During infection of the lung epithelium, Mycobacterium tuberculosis must infect and survive within macrophages long enough to be transported into deeper lung tissues. Cambier et al. (2013) show that pathogenic mycobacteria use the coordinated action of two cell wall glycolipids to regulate macrophage recruitment to initial infection sites.

Publication types

Comment

MeSH terms

Animals
Female
Immune Evasion*
Macrophages / microbiology*
Membrane Lipids / metabolism*
Mycobacterium / physiology*

Substances

Membrane Lipids

Abstract

Publication types

MeSH terms

Substances

Grant support