Experimental aneurysms in the rabbit: occlusion by intrasaccular injection of fibrin sealant

Surg Neurol. 1987 Nov;28(5):361-6. doi: 10.1016/0090-3019(87)90058-9.


Experimental aneurysms of the carotid artery were produced using the microsurgical technique of grafting a venous sack onto the artery in the neck of rabbits after the removal of an elliptical piece of arterial wall. Twenty-five aneurysms were occluded with the fibrin sealant Tissucol. Microscopic examination showed complete resorption of the fibrin clot and the formation of dense granulation tissue within the aneurysm, which was covered with a layer of endothelial cells after 2 weeks. The results are only tentative and require further experimental studies.

MeSH terms

  • Animals
  • Aprotinin / therapeutic use*
  • Drug Combinations / therapeutic use
  • Embolization, Therapeutic*
  • Factor XIII / therapeutic use*
  • Fibrin Tissue Adhesive
  • Fibrinogen / therapeutic use*
  • Injections
  • Intracranial Aneurysm / pathology
  • Intracranial Aneurysm / therapy*
  • Microscopy, Electron, Scanning
  • Rabbits
  • Thrombin / therapeutic use*


  • Drug Combinations
  • Fibrin Tissue Adhesive
  • Fibrinogen
  • Factor XIII
  • Aprotinin
  • Thrombin