Abstract
Aim and methods:
We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous-hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed.
Results and conclusion:
The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).
MeSH terms
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Aged
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Biomarkers, Tumor / analysis
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Carcinoma, Squamous Cell / complications
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / surgery
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Cell Transformation, Neoplastic*
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Cyclin-Dependent Kinase Inhibitor p16 / analysis
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Disease Progression
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Female
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Genotype
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Humans
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Ki-67 Antigen / analysis
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Lichen Sclerosus et Atrophicus / complications
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Lichen Sclerosus et Atrophicus / pathology*
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Male
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Middle Aged
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Papillomaviridae / genetics
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Papillomaviridae / isolation & purification*
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Papillomavirus Infections / complications
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Papillomavirus Infections / pathology*
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Papillomavirus Infections / virology
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Penile Neoplasms / chemistry
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Penile Neoplasms / complications
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Penile Neoplasms / pathology*
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Penile Neoplasms / surgery
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Polymerase Chain Reaction
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Risk Factors
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Skin Neoplasms / chemistry
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Skin Neoplasms / complications
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Skin Neoplasms / pathology*
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Skin Neoplasms / surgery
Substances
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Biomarkers, Tumor
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Cyclin-Dependent Kinase Inhibitor p16
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Ki-67 Antigen