Molecular Diagnosis of Helicobacter Pylori Strain by 16S rDNA PCR Amplification and Direct Sequencing

J Bioprocess Biotech. 2011 Oct 19:1:105e. doi: 10.4172/2155-9821.1000105e.

Abstract

Aim: Rapid detection of H.pylori strains by PCR-Sequencing.

Methods: 16S rDNA amplification by PCR from template genomic DNA, confirmation of amplicon size by agarose gel electrophoresis, sequencing of amplicons by automated sequencer, analysis of sequences by NCBI -BLAST software.

Results: The PCR -Sequencing and analysis of the sequence data by BLAST resulted in detection of the strain to be of H.pylori strain#26695.

Conclusion: The pathogenicity of H.pylori depends on the strain of the bacteria, PCR-Sequencing and analysis of the sequence data by BLAST can be a very quick and useful diagnostic method of the pathogen.

Keywords: BLAST; DNA sequencing; H.pylori; Pcr.