[Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus]

Abstract

The therapeutic armamentarium for the treatment of hyperglycemia in type 2 diabetes mellitus is still inadequate. We are currently witnessing the introduction of a new mode of hypoglycemic treatment through induction of glycosuria to decrease the availability of the metabolic substrate, i.e. glucose. Clinical trials have shown that sodium-glucose co-transporter-2 (SGLT2) inhibitors are as efficacious as other oral hypoglycemic drugs. This article discusses the basic features of this new treatment concept and the efficacy and safety of this new drug group.

Keywords: Diabetes mellitus tipo 2; Efficacy; Eficacia; Glucosuria; Glycosuria; Inhibidores del cotransportador sodio/glucosa tipo 2; Safety; Seguridad; Type 2 diabetes mellitus; Type 2 sodium/glucose co-transporter inhibitors.