The roles of Pellino E3 ubiquitin ligases in immunity

Nat Rev Immunol. 2014 Feb;14(2):122-31. doi: 10.1038/nri3599. Epub 2014 Jan 21.


Pellino proteins were initially characterized as a family of E3 ubiquitin ligases that can catalyse the ubiquitylation of interleukin-1 receptor-associated kinase 1 (IRAK1) and regulate innate immune signalling pathways. More recently, physiological and molecular roles for members of the Pellino family have been described in the regulation of innate and adaptive immune responses by ubiquitylation. This Review describes the emerging roles of Pellino proteins in innate and adaptive immunity and discusses the mechanistic basis of these functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate
  • Nod2 Signaling Adaptor Protein / physiology
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / physiology*
  • Protein Processing, Post-Translational
  • Signal Transduction
  • Toll-Like Receptors / physiology
  • Ubiquitin-Protein Ligases / chemistry
  • Ubiquitin-Protein Ligases / physiology*


  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein
  • Nuclear Proteins
  • Peli2 protein, mouse
  • Toll-Like Receptors
  • PELI1 protein, human
  • PELI3 protein, human
  • Ubiquitin-Protein Ligases