Nrf1 to the rescue

Elife. 2014:3:e02062. doi: 10.7554/eLife.02062. Epub 2014 Jan 21.

Abstract

When the level of proteasomal activity in a cell drops off, a transcription factor called Nrf1 travels to the nucleus to activate the genes that code for proteasomes.

Keywords: Nrf1; p97; proteasomes.

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Cell Cycle Proteins / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Nuclear Respiratory Factor 1 / metabolism*
  • Proteasome Endopeptidase Complex / drug effects*
  • Proteasome Inhibitors / pharmacology*

Substances

  • Cell Cycle Proteins
  • Nuclear Respiratory Factor 1
  • Proteasome Inhibitors
  • Proteasome Endopeptidase Complex
  • Adenosine Triphosphatases