mRNA deadenylation by Pan2-Pan3

Biochem Soc Trans. 2014 Feb;42(1):184-7. doi: 10.1042/BST20130211.


Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'→5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2-Pan3 deadenylation complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Exoribonucleases / physiology*
  • Gene Expression Regulation
  • Humans
  • Polyadenylation
  • RNA Stability
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*


  • Carrier Proteins
  • PAN3 protein, human
  • RNA, Messenger
  • Exoribonucleases
  • PAN2 protein, human