Designer phenethylamines routinely found in human urine: 2-ethylamino-1-phenylbutane and 2-amino-1-phenylbutane

J Anal Toxicol. 2014 Mar;38(2):106-9. doi: 10.1093/jat/bkt121. Epub 2014 Jan 22.


2-Ethylamino-1-phenylbutane (EAPB) and 2-amino-1-phenylbutane (APB) were identified by gas chromatography-mass spectrometry in multiple urine samples submitted for stimulant drug testing and screened positive for amphetamines by enzyme immunoassay. Forty-two samples from all over the USA were found, containing both analytes during a 3-month period May-July 2013. A sports dietary supplement 'CRAZE' has been determined to be one of the sources of EAPB supply. EAPB along with its suggested metabolite APB were detected in a urine sample, obtained from a person known to use 'CRAZE'.

MeSH terms

  • Butylamines / urine*
  • Dietary Supplements / analysis*
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Performance-Enhancing Substances / urine*
  • Phenethylamines / urine*
  • Predictive Value of Tests
  • United States
  • Urinalysis


  • 2-amino-1-phenylbutane
  • Butylamines
  • Performance-Enhancing Substances
  • Phenethylamines
  • N-ethyl-alpha-ethyl-phenethylamine