Detrimental Role of Humoral Signalling in Cardio-Renal Cross-Talk

Crit Care. 2014 Jan 22;18(1):404. doi: 10.1186/cc13704.


In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.

Publication types

  • Comment

MeSH terms

  • Acute Kidney Injury / physiopathology*
  • Cardio-Renal Syndrome*
  • Heart / physiopathology*
  • Heart Failure / physiopathology*
  • Humans
  • Kidney / physiopathology*