Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis

Mediators Inflamm. 2013;2013:510243. doi: 10.1155/2013/510243. Epub 2013 Dec 21.

Abstract

We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA. Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA. In comprehensive confounder adjusted mixed regression models, 5 conventional and 4 nonconventional cardiovascular risk factors were associated (P = 0.05 to <0.0001) with endothelial activation. Interleukin-6 was the only risk factor related to each endothelial activation molecule and independently contributed by 18% and significantly more than other risk factors to the variation in overall endothelial activation as estimated by an SD (z) score of endothelial activation molecule concentrations. The independent interleukin-6-overall endothelial activation relationships were reproduced in various subgroups. Interleukin-6 concentrations relate consistently, markedly, and to a larger extent than other cardiovascular risk factors to endothelial activation in RA. Assessment of interleukin-6 concentrations may enhance cardiovascular risk stratification in RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / complications*
  • Blood Sedimentation
  • Cardiovascular Diseases / etiology
  • Chemokine CCL2 / blood
  • Endothelium, Vascular / physiology*
  • ErbB Receptors / physiology
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Resistin / blood
  • Vascular Cell Adhesion Molecule-1 / blood

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • IL6 protein, human
  • Interleukin-6
  • RETN protein, human
  • Resistin
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • ErbB Receptors