Bleomycin-induced pulmonary nodules: a variant of bleomycin pulmonary toxicity

Gynecol Oncol. 1987 Nov;28(3):284-91. doi: 10.1016/0090-8258(87)90174-0.


Bleomycin has been associated with pulmonary toxicity which is typically manifested as an interstitial pneumonitis resulting in fine, diffuse reticular or reticulomicronodular infiltrates. Attention is drawn to an additional radiologic appearance where discrete pulmonary nodules are seen and representative of bleomycin-induced change. The pitfalls of interpreting such changes as toxic effects versus metastatic disease and proposed mechanisms of bleomycin pulmonary toxicity are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bleomycin / adverse effects*
  • Bleomycin / therapeutic use
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung Diseases / chemically induced*
  • Lung Diseases / diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Ovarian Neoplasms / drug therapy
  • Radiography


  • Bleomycin