Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India

Diabetes Res Clin Pract. 2014 Mar;103(3):e18-23. doi: 10.1016/j.diabres.2013.12.044. Epub 2014 Jan 6.

Abstract

Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFα and IL6). Baseline vitamin-D and 2h blood glucose independently predicted progression to diabetes.

Keywords: Diabetes; Insulin resistance; Prediabetes; Systemic inflammation; Vitamin-D.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / mortality
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Dietary Supplements
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • India
  • Inflammation / drug therapy
  • Inflammation / mortality
  • Inflammation / prevention & control*
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Prediabetic State / blood
  • Prediabetic State / drug therapy*
  • Prognosis
  • Prospective Studies
  • Survival Rate
  • Vitamin D / administration & dosage*
  • Vitamin D Deficiency / mortality
  • Vitamin D Deficiency / prevention & control
  • Vitamins / administration & dosage*

Substances

  • Blood Glucose
  • Vitamins
  • Vitamin D