Diagnostic performance of the QuantiFERON-TB Gold In-Tube assay and factors associated with nonpositive results in patients with miliary tuberculosis

Clin Infect Dis. 2014 Apr;58(7):986-9. doi: 10.1093/cid/ciu045. Epub 2014 Jan 22.

Abstract

The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay provides suboptimal diagnostic performance in patients with miliary tuberculosis. QFT-GIT results should be carefully interpreted, particularly in patients suspected of having miliary tuberculosis with severe lymphocytopenia or an extent of ground glass opacity (GGO) >50% on chest computed tomography (CT). Diagnostic performance of the QFT-GIT assay was evaluated in 44 patients with miliary tuberculosis. Among these individuals, 30 (68%) had true-positive QFT-GIT results. Severe lymphocytopenia and an extent of GGO >50% on chest CT were independent risk factors for nonpositive QFT-GIT results.

Keywords: QuantiFERON-TB Gold In-Tube assay; interferon-gamma release assay; miliary tuberculosis.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • False Negative Reactions
  • Female
  • Humans
  • Interferon-gamma Release Tests / methods*
  • Male
  • Middle Aged
  • Risk Factors
  • Sensitivity and Specificity
  • Tuberculosis, Miliary / diagnosis*