Topography-based keratoconus progression after corneal collagen crosslinking

Cornea. 2014 Apr;33(4):419-21. doi: 10.1097/ICO.0000000000000064.


Purpose: The aim of this study was to report 2 cases with topographic keratoconus progression despite stability for a long-term period after corneal collagen crosslinking (CXL).

Methods: This is a case report.

Results: Two patients with progressive keratoconus underwent CXL treatment. Four and 5 years postoperatively, a topographic examination revealed an increase in the keratometric values indicating keratoconus progression.

Conclusions: Post-CXL, topographic keratoconus progression may occur several years after, despite stability for a long-term period.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Collagen / metabolism*
  • Corneal Stroma / metabolism*
  • Corneal Topography*
  • Cross-Linking Reagents / therapeutic use*
  • Disease Progression
  • Follow-Up Studies
  • Humans
  • Keratoconus / diagnosis*
  • Keratoconus / drug therapy
  • Male
  • Photosensitizing Agents / therapeutic use*
  • Riboflavin / therapeutic use
  • Ultraviolet Rays
  • Visual Acuity / physiology


  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Collagen
  • Riboflavin