Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis

Dirk P Dittmer

doi:10.1182/blood-2013-11-537076

Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis

Blood. 2014 Jan 23;123(4):460-1. doi: 10.1182/blood-2013-11-537076.

Author

Dirk P Dittmer¹

Affiliation

¹ UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL.

Abstract

In this issue of Blood, Fish et al uncover how Epstein-Barr virus (EBV) enhances MYC-driven B-cell lymphoma by crossing EBV Em-EBV latent membrane protein 2A (LMP2A) transgenic mice with immunoglobulin-l (Igl)-MYC transgenic mice.

Publication types

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MeSH terms

Animals
Gene Expression Regulation, Neoplastic*
Humans
Lymphoma, B-Cell / metabolism*
Proto-Oncogene Proteins c-myc / metabolism*
Viral Matrix Proteins / metabolism*

Substances

EBV-associated membrane antigen, Epstein-Barr virus
Proto-Oncogene Proteins c-myc
Viral Matrix Proteins