The non-surgical treatment of peyronie disease: 2013 update

Abstract

Peyronie disease is a common cause of penile deformity and sexual dysfunction. Although surgery is regarded as the definitive management for this condition, there are many medical and minimally invasive therapies available, with widely varying efficacy reported in the literature. The purpose of this review is to describe the current state-of-the-art for each of the most commonly used as well as several developing non-surgical treatments. Further, we hope to offer perspectives that will aid practitioners in deciding among these treatments that are either already in use or have the potential to be used as alternatives to surgery in the management of this frustrating disease.

Keywords: Erectile dysfunction; Penile induration; Peyronie's disease; Pharmacologic therapy; Practice guideline.

Fig. 1

The deformities caused by Peyronie disease are many and varied. All patients appearing in this figure were intracavernosally injected with alprostadil to induce erection prior to photography. The pictures illustrate a dorsal bend with skin buckling (A), a pure lateral bend (B), a more gradual dorsal curvature (C), a dorsal curve with rotational deformity (as evidenced by the laterally displaced frenulum) (D), a circumferential plaque creating a 'waist' effect (E), and a ventral curve caused by a ventral plaque (F).