Ethanol embolotherapy of vascular malformations: clinical outcomes at a single center

J Vasc Interv Radiol. 2014 Feb;25(2):206-13; quiz 214. doi: 10.1016/j.jvir.2013.10.055.

Abstract

Purpose: To retrospectively evaluate the results of endovascular therapy of vascular malformations principally treated with ethanol embolization at a single center.

Materials and methods: From May 1999 to December 2012, 46 patients (28 female, 18 male) with vascular malformations (31 venous malformations, 15 arteriovenous malformations [AVMs]) throughout the body (nine upper extremity, 31 lower extremity, and six truncal) who underwent ethanol embolization were studied and followed up. Demographic factors, clinical findings, imaging data, and patient-reported changes in symptoms were collected and analyzed. Follow-up data were obtained by office visits, repeat imaging, and telephone contact.

Results: Twenty-four patients (52.2%) were considered cured, 12 (26.1%) showed improvement, and 10 (21.7%) had no change or showed worsening. Similar rates of cure or improvement were seen for AVMs and venous malformations (P = 0.67). Lesion location, depth, and size were not associated with differences in outcomes (P = .87, P = .37, and P = .61, respectively). Type 1 and type 2 AVMs were cured more often than other AVM types. The overall complication rate was 24% (11 of 46 patients). Minor complications were seen in six individuals (13%), and major complications developed in five patients (11%).

Conclusions: Ethanol embolization of vascular malformations produces good outcomes, with control or relief of symptoms in a majority of patients.

Keywords: AVM; arteriovenous malformation.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Embolization, Therapeutic / adverse effects
  • Embolization, Therapeutic / methods*
  • Endovascular Procedures / adverse effects
  • Endovascular Procedures / methods*
  • Ethanol / administration & dosage*
  • Ethanol / adverse effects
  • Female
  • Humans
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Vascular Malformations / diagnosis
  • Vascular Malformations / therapy*
  • Young Adult

Substances

  • Ethanol