Male infertility: decreased levels of selenium, zinc and antioxidants

J Trace Elem Med Biol. 2014 Apr;28(2):179-185. doi: 10.1016/j.jtemb.2013.12.005. Epub 2013 Dec 31.


In this study, we aimed to compare the level of zinc, selenium, glutathione peroxidase activity and antioxidant status in following populations of men: severe inflammation in prostate (>10(6) white blood cells in prostate secretion; n=29), severe leukocytospermia, (>10(6) white blood cells in semen; n=31), mild inflammation, (0.2-1M white blood cells in semen or prostate secretion; n=24), non-inflammatory oligozoospermia (n=32) and healthy controls (n=27). Male partners of infertile couples had reduced level of antioxidative activity, selenium and zinc in their seminal plasma. Most importantly, reduced selenium levels were evident in all patient groups regardless of inflammation status. Therefore, these patients might gain some benefit from selenium supplementation.

Keywords: Antioxidants; Infertility; Oligozoospermia; Selenium; Zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / metabolism*
  • Humans
  • Infertility, Male / blood*
  • Inflammation / blood
  • Male
  • Oligospermia / blood
  • Selenium / blood*
  • Zinc / blood*


  • Antioxidants
  • Selenium
  • Zinc