Ultrasound mediated transdermal drug delivery

Aharon Azagury; Luai Khoury; Giora Enden; Joseph Kost

doi:10.1016/j.addr.2014.01.007

Ultrasound mediated transdermal drug delivery

Adv Drug Deliv Rev. 2014 Jun:72:127-43. doi: 10.1016/j.addr.2014.01.007. Epub 2014 Jan 22.

Authors

Aharon Azagury¹, Luai Khoury², Giora Enden², Joseph Kost³

Affiliations

¹ Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel.
² Department of Biomedical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel.
³ Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel. Electronic address: kost@bgu.ac.il.

PMID: 24463344
DOI: 10.1016/j.addr.2014.01.007

Abstract

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.

Keywords: Models and simulations; Safety; Sonophoresis; Synergistic effects of ultrasound; Transdermal drug delivery; Transport phenomena; Ultrasound.

Publication types

Review

MeSH terms

Administration, Cutaneous
Animals
Drug Delivery Systems*
Genetic Therapy
Humans
Immunization / methods
Models, Biological
Skin / metabolism*
Ultrasonics*