Scale-up of malaria rapid diagnostic tests and artemisinin-based combination therapy: challenges and perspectives in sub-Saharan Africa

PLoS Med. 2014 Jan;11(1):e1001590. doi: 10.1371/journal.pmed.1001590. Epub 2014 Jan 21.


Guido Bastiaens and colleagues describe barriers to achieving scale-up and appropriate use of rapid diagnostic tests and artemisinin-based combination therapy for malaria in sub-Saharan Africa.

Please see later in the article for the Editors' Summary

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa South of the Sahara
  • Antimalarials / therapeutic use*
  • Artemisinins / therapeutic use*
  • Delivery of Health Care
  • Diagnostic Tests, Routine / statistics & numerical data*
  • Drug Combinations
  • Health Knowledge, Attitudes, Practice
  • Health Policy
  • Humans
  • Malaria / diagnosis*
  • Malaria / drug therapy*
  • Malaria / parasitology


  • Antimalarials
  • Artemisinins
  • Drug Combinations
  • artemisinin

Grants and funding

Guido Bastiaens is a PhD student employed at the Radboud University Medical Center. Teun Bousema is supported through a grant from the Bill & Melinda Gates Foundation, 51991. Toby Leslie is supported by the ACT Consortium with a grant from the Bill & Melinda Gates Foundation through the London School of Hygiene & Tropical Medicine, 39640. The funders had no role in design, analysis, decision to publish, or preparation of the manuscript.