Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population

PLoS One. 2014 Jan 23;9(1):e86007. doi: 10.1371/journal.pone.0086007. eCollection 2014.

Abstract

Background: Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). To predict the degree of risk for chronicity of HBV, this study determined associations with these SNPs.

Methods: The participants for this study were defined into 4 groups; HCC (n = 230), CHB (n = 219), resolved HBV infection (n = 113) and HBV uninfected subjects (n = 123). The HLA-DP SNPs (rs3077, rs9277378 and rs3128917), TCF19 SNP (rs1419881) and EHMT2 SNP (rs652888) were genotyped.

Results: Due to similar distribution of genotype frequencies in HCC and CHB, we combined these two groups (HBV carriers). The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001). The other SNPs rs3128917, rs1419881 and rs652888 were not associated with HBV carriers.

Conclusions: Genetic variations of rs3077 and rs9277378, but not rs3128917, rs1419881 and rs652888, were significantly associated with HBV carriers relative to resolved HBV in Thai population.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / virology
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • HLA-DP alpha-Chains / genetics*
  • HLA-DP beta-Chains / genetics*
  • Hepatitis B, Chronic / genetics*
  • Histocompatibility Antigens / genetics*
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Linkage Disequilibrium
  • Liver Neoplasms / genetics
  • Liver Neoplasms / virology
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Thailand

Substances

  • HLA-DP alpha-Chains
  • HLA-DP beta-Chains
  • HLA-DPA1 antigen
  • HLA-DPB1 antigen
  • Histocompatibility Antigens
  • EHMT2 protein, human
  • Histone-Lysine N-Methyltransferase

Grants and funding

This work was supported by grants from The JSPS RONPAKU (Dissertation PhD) Program; the Ratchadapiseksompotch Endowment Fund of Chulalongkorn University [RES560530155-AM and RES560530093-HR); Higher Education Research Promotion and National Research University Project of Thailand Office of the Higher Education Commission [HR1155A-55 and HR1162A-55]; Thailand Research Fund [DPG5480002 and BRG5580005]; Chulalongkorn University, Integrated Innovation Academic Center, Chulalongkorn University Centenary Academic Development Project [CU56-HR01]; King Chulalongkorn Hospital and the Office of the National Research Council of Thailand (NRCT); grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan and the Ministry of Education, Culture, Sports, Science and Technology, Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.