Integrin cytoplasmic tail interactions

Biochemistry. 2014 Feb 11;53(5):810-20. doi: 10.1021/bi401596q. Epub 2014 Jan 27.


Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism*
  • Cytoskeleton / metabolism
  • Humans
  • Integrins / metabolism*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mechanotransduction, Cellular
  • Signal Transduction*


  • Integrins
  • Intracellular Signaling Peptides and Proteins