Mevalonate metabolism in cancer

Cancer Lett. 2015 Jan 28;356(2 Pt A):192-6. doi: 10.1016/j.canlet.2014.01.013. Epub 2014 Jan 24.


Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to evade immune surveillance. The current review focuses on the metabolic reprogramming of cancer cells and on the immune system's capacity to detect such changes in cancer cell metabolism. Specifically, we focus on mevalonate metabolism, which is a target for drug and immune based cancer treatment.

Keywords: Immune surveillance; Malignancy; Mevalonate; p53.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis
  • Cell Proliferation
  • Energy Metabolism*
  • Glucose / metabolism
  • Glycolysis / physiology
  • Humans
  • Mevalonic Acid / metabolism*
  • Neoplasms / immunology
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Signal Transduction
  • T-Lymphocytes / immunology
  • Tumor Escape / immunology*
  • Tumor Suppressor Protein p53 / metabolism


  • Tumor Suppressor Protein p53
  • Glucose
  • Mevalonic Acid