Abstract
Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chromatin / chemistry
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Chromatin / genetics
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Drosophila / genetics
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism
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Genetic Loci
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Genomics / methods*
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Mice
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Multigene Family
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RNA, Small Interfering / genetics*
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RNA, Small Interfering / metabolism
Substances
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Chromatin
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Drosophila Proteins
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RNA, Small Interfering