Disseminated tuberculosis in 2 children with inflammatory bowel disease receiving infliximab

Pediatr Infect Dis J. 2014 Jul;33(7):779-81. doi: 10.1097/INF.0000000000000286.


Patients with inflammatory bowel disease are predisposed to opportunistic infections. We report 2 cases of disseminated tuberculosis in adolescents receiving a TNF antagonist, infliximab. Both had negative baseline tuberculin skin tests. Multimodal testing using tuberculin skin tests and interferon gamma release assays at the time of inflammatory bowel disease diagnosis and annually may increase the sensitivity of LTBI testing in these high risk children.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal / adverse effects*
  • Antibodies, Monoclonal / therapeutic use*
  • Female
  • Humans
  • Inflammatory Bowel Diseases / complications*
  • Inflammatory Bowel Diseases / drug therapy*
  • Infliximab
  • Interferon-gamma Release Tests
  • Latent Tuberculosis / complications*
  • Male
  • Tuberculin Test
  • Tuberculosis, Miliary / chemically induced*
  • Tuberculosis, Miliary / diagnosis*
  • Tuberculosis, Miliary / pathology


  • Antibodies, Monoclonal
  • Infliximab