Calcium in health and disease
- PMID: 24470090
- DOI: 10.1007/978-94-007-7500-8_4
Calcium in health and disease
Abstract
Evolution has exploited the chemical properties of Ca(2+), which facilitate its reversible binding to the sites of irregular geometry offered by biological macromolecules, to select it as a carrier of cellular signals. A number of proteins bind Ca(2+) to specific sites: those intrinsic to membranes play the most important role in the spatial and temporal regulation of the concentration and movements of Ca(2+) inside cells. Those which are soluble, or organized in non-membranous structures, also decode the Ca(2+) message to be then transmitted to the targets of its regulation. Since Ca(2+) controls the most important processes in the life of cells, it must be very carefully controlled within the cytoplasm, where most of the targets of its signaling function reside. Membrane channels (in the plasma membrane and in the organelles) mediate the entrance of Ca(2+) into the cytoplasm, ATPases, exchangers, and the mitochondrial Ca(2+) uptake system remove Ca(2+) from it. The concentration of Ca(2+) in the external spaces, which is controlled essentially by its dynamic exchanges in the bone system, is much higher than inside cells, and can, under conditions of pathology, generate a situation of dangerous internal Ca(2+) overload. When massive and persistent, the Ca(2+) overload culminates in the death of the cell. Subtle conditions of cellular Ca(2+) dyshomeostasis that affect individual systems that control Ca(2+), generate cell disease phenotypes that are particularly severe in tissues in which the signaling function of Ca(2+) has special importance, e.g., the nervous system.
Similar articles
-
The signaling function of calcium and its regulation.J Hypertens Suppl. 1994 Dec;12(10):S47-56. J Hypertens Suppl. 1994. PMID: 7769491
-
Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection.Antioxid Redox Signal. 2011 Apr 1;14(7):1275-88. doi: 10.1089/ars.2010.3359. Epub 2010 Oct 6. Antioxid Redox Signal. 2011. PMID: 20615073 Free PMC article. Review.
-
Mitochondrial calcium channels.FEBS Lett. 2010 May 17;584(10):1975-81. doi: 10.1016/j.febslet.2010.04.017. Epub 2010 Apr 11. FEBS Lett. 2010. PMID: 20388514 Review.
-
Intracellular calcium regulation, with special attention to the role of the plasma membrane calcium pump.J Cardiovasc Pharmacol. 1988;12 Suppl 3:S77-84. J Cardiovasc Pharmacol. 1988. PMID: 2467110 Review.
-
Abnormal intracellular ca(2+)homeostasis and disease.Cell Calcium. 2000 Jul;28(1):1-21. doi: 10.1054/ceca.2000.0131. Cell Calcium. 2000. PMID: 10942700 Review.
Cited by
-
Combined full-length transcriptomic and metabolomic analysis reveals the molecular mechanisms underlying nutrients and taste components development in Primulina juliae.BMC Genom Data. 2024 May 23;25(1):46. doi: 10.1186/s12863-024-01231-z. BMC Genom Data. 2024. PMID: 38783179 Free PMC article.
-
Essential role of N-terminal SAM regions in STIM1 multimerization and function.Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2318874121. doi: 10.1073/pnas.2318874121. Epub 2024 May 16. Proc Natl Acad Sci U S A. 2024. PMID: 38753510
-
Acamprosate reduces ethanol intake in the rat by a combined action of different drug components.Sci Rep. 2023 Oct 19;13(1):17863. doi: 10.1038/s41598-023-45167-3. Sci Rep. 2023. PMID: 37857829 Free PMC article.
-
Evaluation of the Safety and Potential Benefits of Beetroot-Based Dietary Supplements According to Their Elemental Composition.Biol Trace Elem Res. 2024 Jul;202(7):3318-3332. doi: 10.1007/s12011-023-03902-x. Epub 2023 Oct 7. Biol Trace Elem Res. 2024. PMID: 37804447 Free PMC article.
-
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine.J Cell Commun Signal. 2023 Dec;17(4):1309-1321. doi: 10.1007/s12079-023-00783-6. Epub 2023 Sep 13. J Cell Commun Signal. 2023. PMID: 37702818 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous