Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy

Infect Dis Rep. 2012 Jan 30;4(1):e11. doi: 10.4081/idr.2012.e11. eCollection 2012 Jan 2.


Many cases of cutaneous vasculitis are drug-induced with histology revealing leukocytoclastic vasculitis (LCV). We present a case of levofloxacin-associated LCV successfully treated with prednisone and cessation of the offending drug. Although case reports describe a link between LCV and older fluoroquinolones, such as ciprofloxacin and ofloxacin, recent reports have implicated the newer fluoroquinolone levofloxacin. Recognition of fluoroquinolone-induced cutaneous vasculitis is important as continuation or re-exposure of the offending agent may have life-threatening consequences.

Keywords: drug induced cutaneous vasculitis; fluoroquinolone.; leukocytoclastic vasculitis; levofloxacin.

Publication types

  • Case Reports