Antibodies to sulfated glucuronic acid containing glycosphingolipids in neuropathy associated with anti-MAG antibodies and in normal subjects

J Neuroimmunol. 1988 Jan;17(2):119-26. doi: 10.1016/0165-5728(88)90019-7.


Serum of patients with neuropathy and IgM monoclonal antibodies (M-proteins) that bind to the myelin-associated glycoprotein (MAG) were tested for binding to the major cross-reactive sulfated glucuronic acid containing glycosphingolipid, sulfated glucuronic acid paragloboside (SGPG). IgM binding to the glycolipid was detectable at serum dilutions of 1:10,000 and reactivity was greatest at 4 degrees C. Low titers of IgM binding to the glycolipid were also detected in sera from normal subjects and from patients with neurologic or rheumatologic diseases without serum M-proteins. Binding activity was present in 25% of the sera tested, and titers ranged between 1:25 and 1:400. One patient with peripheral neuropathy, however, had a measurable titer of 1:12,800 in the absence of monoclonal gammopathy. The study indicates that cold reacting anti-SGPG IgM antibodies are frequent constituents of the normal human antibody repertoire, and that monoclonal or polyclonal expansion of B cells that secrete these antibodies, is associated with peripheral neuropathy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal / immunology*
  • Autoantibodies / immunology*
  • Autoimmune Diseases / immunology*
  • Cross Reactions
  • Cryoglobulins / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Globosides / immunology*
  • Glycosphingolipids / immunology*
  • Humans
  • Hypergammaglobulinemia / immunology*
  • Immunoglobulin M / immunology
  • Monoclonal Gammopathy of Undetermined Significance / immunology*
  • Myelin Proteins / immunology*
  • Myelin-Associated Glycoprotein
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / immunology*
  • Rheumatic Diseases / immunology*


  • Antibodies, Monoclonal
  • Autoantibodies
  • Cryoglobulins
  • Globosides
  • Glycosphingolipids
  • Immunoglobulin M
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • sulfate-3-glucuronyl paragloboside