Pentatricopeptide repeat proteins in plants

Annu Rev Plant Biol. 2014;65:415-42. doi: 10.1146/annurev-arplant-050213-040159. Epub 2014 Jan 27.

Abstract

Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis Proteins / chemistry
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Base Sequence
  • Models, Molecular
  • Molecular Sequence Data
  • Plant Proteins / chemistry
  • Plant Proteins / genetics
  • Plant Proteins / metabolism*
  • Plants / genetics
  • Plants / metabolism*
  • Protein Structure, Secondary
  • RNA, Plant / chemistry
  • RNA, Plant / genetics
  • RNA, Plant / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Repetitive Sequences, Amino Acid

Substances

  • Arabidopsis Proteins
  • Plant Proteins
  • RNA, Plant
  • RNA-Binding Proteins
  • pentatricopeptide repeat protein, Arabidopsis