The operating parameters in the electro-Fenton process were simulated using computational fluid dynamics (CFD). The effects of H2O2/Fe(2+) molar ratio, current density, pH and reaction time were numerically investigated. The results were compared with the experimental data. The simulated data showed that maximum chemical oxygen demand (COD) removal was around 91.52% at pH of 3.27, H2O2/Fe(2+) molar ratio of 1.16, current density of 59.29 mA/cm(2) and reaction time of 41.7 min while the experimental data obtained from the literature showed a maximum COD removal (94.7%) at pH of 3, H2O2/Fe(2+) molar ratio of 1, current density of 49 mA/cm(2) and reaction time of 43 min.