Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Mar;71(3):273-5.
doi: 10.1001/jamaneurol.2013.6031.

Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns?

Steven T Dekosky  1 , Sam Gandy  2
Affiliations
Editorial

Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns?

Steven T Dekosky et al. JAMA Neurol. 2014 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: In the past 5 years, Dr DeKosky has served as a consultant for AstraZeneca, Merck, Elan/Wyeth, Novartis, Lilly, Janssen, Helicon Therapeutics, and Genzyme. He has received research grants from Elan, Novartis, Janssen, Pfizer, and Baxter. He serves as an editor for Up To Date. He is founding chair of the International Society to Advance Alzheimer’s Research and Treatment, the Medical and Scientific Advisory Council of the Alzheimer’s Association, and the Medical and Scientific Advisory Panel of Alzheimer’s Disease International. Within the past 5 years, Dr Gandy has received grants from Baxter Pharmaceuticals, Polyphenolics Inc, and Amicus Pharmaceuticals. He has served as a member of the Data and Safety Monitoring Board for the Pfizer-Janssen Alzheimer’s Immunotherapy Alliance, as a member of the Scientific Advisory Board of DiaGenic, and as a consultant to Amicus Pharmaceuticals and Cerora Inc.

Comment in

  • Alzheimer disease risk factors.
    Richardson JR, German D, Levey A. Richardson JR, et al. JAMA Neurol. 2014 Aug;71(8):1051. doi: 10.1001/jamaneurol.2014.1525. JAMA Neurol. 2014. PMID: 25111206 No abstract available.
  • Alzheimer disease risk factors--reply.
    DeKosky ST, Gandy S. DeKosky ST, et al. JAMA Neurol. 2014 Aug;71(8):1051-2. doi: 10.1001/jamaneurol.2014.636. JAMA Neurol. 2014. PMID: 25111207 No abstract available.

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gandy S, DeKosky ST. Toward the treatment and prevention of Alzheimer’s disease: rational strategies and recent progress. Annu Rev Med. 2013;64:367–383. - PMC - PubMed
    1. Jack CR, Jr, Holtzman DM. Biomarker modeling of Alzheimer’s disease. Neuron. 2013;80(6):1347–1358. - PMC - PubMed
    1. Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. European Alzheimer’s Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer’s Disease (GERAD); Alzheimer’s Disease Genetic Consortium (ADGC); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet. 2013;45(12):1452–1458. - PMC - PubMed
    1. Ketelaar ME, Hofstra EM, Hayden MR. What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration. Clin Genet. 2012;81(4):325–333. - PubMed
    1. Cannon JR, Greenamyre JT. The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci. 2011;124(2):225–250. - PMC - PubMed