Endonyx toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye

An Bras Dermatol. Nov-Dec 2013;88(6):1019-21. doi: 10.1590/abd1806-4841.20132180.

Abstract
in En , Portuguese

This study shows the effectiveness of photodynamic therapy based on methylene blue dye for the treatment of endonyx toenail onychomycosis. Four patients with endonyx onychomycosis caused by Trichophyton rubrum were treated with 2% methylene blue aqueous solution irradiated with light emission diode at 630 nm and an energy density of 36 J/cm2 for 6 months at 2-week intervals. The preliminary study showed the effectiveness of this therapy in the treatment of endonyx onychomycosis, and also indicated that the disease can be caused by T. rubrum.

O estudo revelou a eficácia da terapia fotodinâmica com corante azul de metileno para o tratamento da onicomicose endonix podal. Quatro pacientes apresentando onicomicose endonix causada pelo Trichophyton rubrum foram tratados com solução aquosa de azul de metileno a 2% irradiada com diodo emissor de luz com 630 nm e densidade de energia de 36 J/cm2 em sessões quinzenais durante seis meses. O estudo preliminar mostra que essa terapia é eficaz no tratamento da onicomicose endonix e que o T. rubrum pode causar a doença.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Foot Dermatoses / drug therapy*
  • Foot Dermatoses / microbiology
  • Humans
  • Male
  • Methylene Blue / therapeutic use*
  • Nails
  • Onychomycosis / drug therapy*
  • Onychomycosis / microbiology
  • Photochemotherapy / methods*
  • Time Factors
  • Treatment Outcome
  • Trichophyton*

Substances

  • Methylene Blue