Stillbirth during infection with Middle East respiratory syndrome coronavirus

J Infect Dis. 2014 Jun 15;209(12):1870-2. doi: 10.1093/infdis/jiu068. Epub 2014 Jan 28.


We conducted an epidemiologic investigation among survivors of an outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Jordan. A second-trimester stillbirth occurred during the course of an acute respiratory illness that was attributed to MERS-CoV on the basis of exposure history and positive results of MERS-CoV serologic testing. This is the first occurrence of stillbirth during an infection with MERS-CoV and may have bearing upon the surveillance and management of pregnant women in settings of unexplained respiratory illness potentially due to MERS-CoV. Future prospective investigations of MERS-CoV should ascertain pregnancy status and obtain further pregnancy-related data, including biological specimens for confirmatory testing.

Keywords: EMC-CoV; Jordan; MERS-CoV; Middle East respiratory syndrome; birth outcomes; novel coronavirus; pneumonia; pregnancy; severe acute respiratory illness; stillbirth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Coronavirus / isolation & purification*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Female
  • Humans
  • Jordan
  • Pregnancy
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / virology
  • Retrospective Studies
  • Stillbirth / epidemiology*
  • Young Adult