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. 2012 Jul;1(2):81-2.
doi: 10.5812/nephropathol.7475. Epub 2012 Jul 1.

Erythropoietin; Bright Future and New Hopes for an Old Drug

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Free PMC article

Erythropoietin; Bright Future and New Hopes for an Old Drug

Mehri Kadkhodaee. J Nephropathol. .
Free PMC article

Abstract

Recent publications have suggested renoprotective actions for erythropoietin in certain models of acute kidney injury. In a study by Rafieian-Kopaei et al., the effects of erythropoietin on amelioration of gentamicin-induced renal toxicity was investigated and renoprotective effect for Eprex, an analogue of erythropoietin was shown when the drug was given in combination with gentamicin. There has also been a protective effect when the drug was applied after gentamicin administration. Thus, the drug was effective even after induction of tubular damage which opens a very valuable window for its therapeutic actions. However, there are still needs for studies on the mechanisms which are involved in these protective actions.

Keywords: Erythropoietin; Gentamicin; Nephrotoxicity; Renoprotection.

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  • J Nephropathol. 1:109.

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