Clinical outcomes of using lasers for peri-implantitis surface detoxification: a systematic review and meta-analysis

J Periodontol. 2014 Sep;85(9):1194-202. doi: 10.1902/jop.2014.130620. Epub 2014 Jan 30.


The aim of this systematic review is to compare the clinical outcomes of lasers with other commonly applied detoxification methods for treating peri-implantitis. An electronic search of four databases and a hand search of peer-reviewed journals for relevant articles were conducted. Comparative human clinical trials and case series with ≥ 6 months of follow-up in ≥ 10 patients with peri-implantitis treated with lasers were included. Additionally, animal studies applying lasers for treating peri-implantitis were also included. The included studies had to report probing depth (PD) reduction after the therapy.

Results: Seven human prospective clinical trials and two animal studies were included. In four and three human studies, lasers were accompanied with surgical and non-surgical treatments, respectively. The meta-analyses showed an overall weighted mean difference of 0.00 mm (95% confidence interval = -0.18 to 0.19 mm) PD reduction between the laser and conventional treatment groups (P = 0.98) for non-surgical intervention. In animal studies, laser-treated rough-surface implants had a higher percentage of bone-to-implant contact than smooth-surface implants. In a short-term follow-up, lasers resulted in similar PD reduction when compared with conventional implant surface decontamination methods.

Keywords: Decontamination; dental implants; laser therapy; lasers; meta-analysis; peri-implantitis.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Dental Implants* / microbiology
  • Disinfection / methods
  • Humans
  • Laser Therapy / methods*
  • Lasers / classification
  • Peri-Implantitis / surgery*
  • Treatment Outcome


  • Dental Implants