Signalling between microvascular endothelium and cardiomyocytes through neuregulin

Cardiovasc Res. 2014 May 1;102(2):194-204. doi: 10.1093/cvr/cvu021. Epub 2014 Jan 29.


Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.

Keywords: ErbB; Heart; Heterocellular communication; Neuregulin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endothelium / metabolism*
  • Heart Diseases / metabolism
  • Humans
  • Microvessels / metabolism*
  • Myocytes, Cardiac / metabolism*
  • Neuregulins / genetics
  • Neuregulins / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology*


  • Neuregulins