Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions

Org Biomol Chem. 2014 Mar 14;12(10):1649-51. doi: 10.1039/c4ob00166d.


A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure


  • Indoles