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. 2014 Mar 14;12(10):1649-51.
doi: 10.1039/c4ob00166d.

Towards a Facile and Convenient Synthesis of Highly Functionalized Indole Derivatives Based on Multi-Component Reactions

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Free PMC article

Towards a Facile and Convenient Synthesis of Highly Functionalized Indole Derivatives Based on Multi-Component Reactions

Constantinos G Neochoritis et al. Org Biomol Chem. .
Free PMC article

Abstract

A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps.

Figures

Fig 1
Fig 1
Selected examples of indole-containing compounds
Fig 2
Fig 2
Multi-Component Reactions of the novel isocyanide
Scheme 1
Scheme 1
Retrosynthetic analysis of 1H-indole-methyl-isocyanide 2
Scheme 2
Scheme 2
The Leuckart-Wallach reaction and synthesis of the isocyanide 2
Scheme 3
Scheme 3
Synthesis of a tris-indole alkaloid-like compound

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