Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress

Front Behav Neurosci. 2014 Jan 21:7:224. doi: 10.3389/fnbeh.2013.00224. eCollection 2013.


Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.

Keywords: Arc/Arg3.1; brain-derived neurotrophic factor; gene expression; long-term potentiation; mood disorder; sleep deprivation; stress; translation control.

Publication types

  • Review